Trichomoniasis in women
Trichomoniasis in women (urethritis and vaginitis) Flags administered a single dose of 2 g or as a course of treatment for 10 days: 1 tab. (250 mg) 2 times/day. Trichomoniasis in men (urethritis) Flags administered a single dose of 2 g or as a course of treatment for 10 days on 1 tab. (250 mg) 2 times/day. When nonspecific vaginitis used 500 mg of Flagyl 2 times/day for 7 days. In the treatment of anaerobic infections adults appoint Flags at 1-1.5 g/day. When expressed violations kidney (KK less 10 ml/min) is recommended to reduce the daily dose in 2 times. Drug interactions Similar to disulfiram causes intolerance to ethanol. Concurrent use with disulfiram may lead to the development of various neurological symptoms (the interval between the appointment - at least 2 weeks). Enhances the effect of indirect anticoagulants, resulting in increased time, the formation of prothrombin.
Cimetidine inhibits the metabolism of metronidazole, which can lead to the increase of its concentration in serum and increased risk of side effects. Coadministration of drugs that stimulate the enzymes of microsomal oxidation in the liver (phenobarbital, phenytoin), may accelerate the elimination of metronidazole, resulting in reduced its concentration in plasma. Pregnancy and lactation Contraindication: pregnancy and breastfeeding. Side effects Gastrointestinal: nausea, metallic taste in mouth, dry mouth, loss of appetite, glossitis, stomatitis, pancreatitis, anorexia, epigastric pain, vomiting, diarrhea, constipation. Nervous system: headache, dizziness, incoordination, ataxia, confusion, irritability, depression, irritability, weakness, insomnia, convulsions, confusion, hallucinations, peripheral neuropathy (especially with prolonged use). Allergic reactions: urticaria, skin rash, skin flushing, nasal congestion, fever, arthralgia. Urinary system: dysuria, polyuria, cystitis, urinary incontinence, candidiasis, possible staining of urine reddish-brown color. Other: neutropenia, leukopenia, flattening of the T wave on the ECG. The terms and conditions of storage List B. the Drug should be stored at a temperature not exceeding 25°C, out of reach of children. Shelf life - 5 years. Do not use after the expiry date printed on the package. Readings — a protozoan infection: extra-intestinal amebiasis, including amebic liver abscess, intestinal amebiasis (amebic dysentery), trichomoniasis, balantidiasis, giardiasis, cutaneous leishmaniasis, Trichomonas vaginitis, Trichomonas urethritis; infection, caused by Bacteroides spp. (incl. Bacteroides fragilis, Bacteroides distasonis, Bacteroides ovatus, Bacteroides thetaiotaomicron, Bacteroides vulgatus): infections of bones and joints, infections of the Central nervous system, including meningitis, brain abscess, bacterial endocarditis, pneumonia, empyema and lung abscess, sepsis; infection caused by species of Clostridium spp. Peptococcus and Peptostreptococcus: infection of the abdominal cavity (peritonitis, liver abscess), infections of the pelvic organs (endometritis, abscess of the fallopian tubes and ovaries, infections of the vaginal fornix); — pseudomembranous colitis (caused by antibiotics); gastritis or duodenal ulcer associated with Helicobacter pylori (integrated therapy); — prevention of postoperative complications (especially interventions on the colon, pararectal region, appendectomy, gynecologic surgery). Contraindications organic CNS lesions; — blood disorders, including leucopenia in history; — liver failure (in the case of appointment of large doses); — pregnancy; — breastfeeding; — children up to age 6 years; — hypersensitivity to imidazolov. Special instructions
Because coadministration of the drug with alcohol can have an effect similar to the effect of disulfiram (hot flashes, vomiting, tachycardia), you should warn patients that during the treatment Flagellum should not consume alcoholic beverages or medications containing alcohol. The long-term administration of the preparation is preferably carried out under the control of the blood formula. Leukopenia the possibility of further treatment depends on the risk of development of infectious process. In the treatment of Trichomonas vaginitis in women and Trichomonas urethritis in men should refrain from sexual activity. Necessarily simultaneous treatment of sexual partners. Treatment does not stop during menstruation. After therapy for trichomoniasis should conduct a control sample for 3 regular cycles before and after menstruation. After the treatment of giardiasis, if symptoms persist, after 3-4 weeks to spend 3 analysis of feces at intervals of several days (some successfully treated patients with lactose intolerance, caused by infestation may persist for several weeks or months, reminding the symptoms of giardiasis). Should discontinue treatment with the appearance of ataxia, dizziness, hallucinations, worsening of the neurological status of patients. You must take into account that metronidazole can be immobilized Treponema, which leads to false-positive test Nelson. Effects on ability to drive vehicles and management mechanisms In connection with the possibility of dizziness and other side effects associated with taking the drug, it is recommended to refrain from driving and other mechanisms. When kidney functions When expressed violations kidney (KK less 10 ml/min) is recommended to reduce the daily dose in 2 times.Use in children Contraindications: children under 6 years. Giardiasis is treated for 5 days: children 6-10 years in the 375 mg/day (1.5 tab.) and children 10-15 years - 500 mg/day (2 tab.). For children under 6 years of age is preferable to the use of metronidazole in the form of aspasie. Conditions of supply of pharmacies The drug is available by prescription. Description of the preparation FLAG is based on the approved instructions for use and approved by the manufacturer.
1. "Milanovic & partners" has prepared and defended more than 200 investment projects of different directions. 2. Our ongoing market research exhaustively characterize the situation in your industry and help to identify the most suitable regions for realization. 3. We explain all the nuances of your project, and provide the necessary assistance and information support at the stage of its protection. Counterparts. METROGYL. Clinico-pharmacological group Antiprotozoal drug with antibacterial activity Release form, composition and packaging Tablets, film-coated pink, round, lenticular. 1 tab. metronidazole 200 mg Auxiliary substances: corn starch, magnesium stearate, colloidal silicon dioxide, castor oil gidrirovannoe, dye e II pink 85G54815, purified water. 10 PCs. - blisters (2) - packs of cardboard. 10 PCs. - blisters (10) - packs of cardboard. Tablets, film-coated orange, round, lenticular. 1 tab. metronidazole 400 mg Auxiliary substances: corn starch, povidone, magnesium stearate, colloidal silicon dioxide, dye e II orange 85G53070, purified water. 10 PCs. - blisters (2) - packs of cardboard. 10 PCs. - blisters (10) - packs of cardboard. Pharmacological action Metronidazole is an Antiprotozoal and antibacterial agent broad-spectrum. The mechanism of action of the drug is to restore the 5-nitro group of metronidazole intracellular transport proteins of anaerobic microorganisms and protozoa. Reconditioned 5-nitro group of metronidazole interacts with DNA cell of microorganisms by inhibiting the synthesis of nucleic acids, which leads to the death of bacteria. Pharmacokinetics After ingestion of a single dose of 200 mg or 400 mg metronidazole is rapidly and completely absorbed, reaching Cmax in plasma (6 mg, 12 mg) after 2 h. AUC is 35 µg/ml/h and 69 µg/ml/h, respectively. Has high penetrability into tissues (lungs, kidneys, liver, skin), spinal fluid, brain, bile, saliva, amniotic fluid, vaginal secretions, semen, breast milk. Relationship with blood plasma proteins - 10-20%. Excreted by the kidneys (60-80% of the dose), 20% of drug is excreted unchanged. T1/2 is 8 h. Renal clearance is 10 ml/min. In patients with impaired renal function after repeated injection can be observed accumulation of metronidazole in serum (in patients with severe renal insufficiency daily dose of metronidazole should be reduced).